Expression of an IFN-Inducible Cellular Senescence Gene, IFI16, Is Up-Regulated by p53
نویسندگان
چکیده
منابع مشابه
Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53.
IFN-inducible IFI16 protein (encoded by IFI16 gene at 1q23.1) is the human member of the IFN-inducible structurally related p200 family proteins. Increased expression of the IFI16 protein, a positive modulator of p53-mediated transcription, in normal old human diploid fibroblasts (HDF) is associated with cellular senescence-mediated cell growth arrest. However, the underlying mechanisms that co...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2008
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-08-0208